Corona Pre-Exploration Project
The Corona Pre-Exploration Project is committed to contributing to the sustained control and prophylaxis of infections caused by SARS-CoV-2. It is a collaboration between several researchers from Charité, HU Berlin, FU Berlin, RKI and TU Berlin within the Berlin University Alliance (BUA).
The project is divided in five research areas:
1) Generation and testing of antiviral therapy and prevention concepts
2) 2- and 3-dimensional human tissue models of SARS-CoV-2 infection
3) Development of sustainable vaccines
4) Animal and surrogate models of SARS-CoV-2 infection
5) Disease progression and predictive markers
6) Modelling of SARS-CoV-2 pandemic distribution consequences
The Department of Healthcare Management contributes to research area 6 by analysing the pandemic’s impact on the healthcare system in Germany and other European countries. To do so, a database encompassing data on COVID-19 cases, tests, hospitalisations, ICU treatment and ventilation from 30 European countries and two Italian regions was developed in March 2020. Since then, the database has been updated daily, and is made publicly available on our website . Data has been gathered from official online sources such as websites of ministries of health, national research and public health institutes, official dashboards from national institutions, Our World in Data (OWiD) and the European Centre for Disease Prevention and Control (ECDC). There is a broad interest in our data, e.g. from the World Health Organization (WHO), the European Commission and the Institute for Health Metrics. The database has served as a tool to understand capacity needs for different waves in the SARS-CoV-2 pandemic, and is being further developed as a preparedness tool for future outbreaks.
In addition to the database, other data sources are being used to assess the impact of COVID-19 on the German health system, including the data of hospitalized COVID-19 patients insured by AOK or nation-wide routine data on non-COVID-19 patients from the Institute for the Hospital Remuneration Systems (InEK). To complement information, data from the ambulatory sector will also be included in the analyses. Furthermore, expenditure figures and Public Health measures are taken into account, e.g. from the COVID-19 Health System Response Monitor (HSRM) .
More information on the BUA and the whole project is available at: Corona Virus Pre-Exploration Project • Berlin University Alliance (berlin-university-alliance.de) 
Funding: The project is funded with €1.8 million by by the Ministry of Education and Research (BMBF) and the federal state of Berlin (112_PreEP_Corona).
Berger E, Reichebner C, Eriksen A, Kretzler M, Offermanns M, Heber R, Krause C, Busse R (2020): COVID-19 als Stresstest für das Gesundheitssystem: Eine Bestandsaufnahme der Situation in Dänemark und Deutschland.  DOI: 10.5771/1611-5821-2020-4-5-49 
Karagiannidis C, Mostert C, Hentschker C, Voshaar T, Malzahn J, Schillinger G, Klauber J, Janssens U, Marx G, Weber-Carstens S, Kluge S, Pfeifer M, Grabenhenrich L, Welte T, Busse R (2020): Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals_ an observational study.  DOI: doi.org/10.1016/S2213-2600(20)30316-7 
Millar JE, Busse R, Fraser JF, Karagiannidis C, McAuley DF (2020): Apples and oranges: international comparisons of COVID-19 observational studies in ICUs.  DOI: doi.org/10.1016/S2213-2600(20)30368-4 
Dataset including data from February to July 2020 in machine readable format: https://doi.org/10.7910/DVN/02CFBB 
Elke Berger , Juliane Winkelmann , Reinhard Busse, Helene Eckhardt, Joan Kleine, Hendrikje Lantzsch, Ulrike Nimptsch, Dimitra Panteli, Christoph Reichebner, Tanja Rombey, Lukas Schöner
+49 30 314 28702
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+49 30 314 22627
Room Raum 9113
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